Multiphoton Imaging of Breast Cancer

Clinnovate Health UK, presented at the Glasgow Molecular Pathology Node Symposium 2017, University of Glasgow.

Systematic Quantitation of Histologic Patterns Shows Accuracy in Reflecting Cirrhotic Remodelling

Wang Y, Huang W, Li R, Yun Z, Zhu Y, Yang J, Liu H, Liu Z, Feng Q, Hou J. J Gastroenterol Hepatol. 2017 Jan 9. doi: 10.1111/jgh.13722. [Epub ahead of print].

Dual-photon Microscopy-based Quantitation of Fibrosis-related Parameters (q-FP) to Model Disease Progression in Steatohepatitis

Wang Y, Vincent R, Yang J, Asgharpour A, Liang X, Idowu MO, Contos MJ, Daitya K, Siddiqui MS, Mirshahi F, Sanyal AJ. Hepatology. 2017 Jun;65(6):1891-1903. doi: 10.1002/hep.29090. Epub 2017 Apr 28.

Novel Methods in Imaging and Quantification of Skeletal Muscle Fibrosis Associated with Severe Muscular Dystrophy.

David W. Hammers, Coar C. Coker, Li Chen, Matt Petitjean, Elizabeth R.  Barton, H.Lee Sweeney presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017.

Use of Second Harmonic Generation (SHG) and 2-Photon Emission Imaging to Quantify and Describe the Structure of Tissue Fibrosis in the Rat TNBS Intestinal Fibrosis Model.  

Laura Johnson, Li.Chen, P. Higgings et all. Poster #2008 presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017.

Concurrent Semi-Automated Quantification of Liver Fibrosis and Fat Using Label-free Second Harmonic Generation Imaging in Animal Models.

M. Petitjean, J. Schwartz, Li Chen. Poster #3003 - presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017.

Quantification of Septa in Liver Fibrosis Using Second Harmonic Generation Imaging

Li Chen, Mohammad Naser,  et all. Poster #1016 - presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017.

Comparative Efficacy of INT-767 Vs. Liraglutide in Gubra AMLN Mice.

Jonathan Roth et All. Intercept Pharmaceuticals. Keystone Symposia Workshop: approaches to NASH Treatment, March 7th 2017.

Quantitative Imaging of Fibrotic and Morphological Changes in Liver of Nonalcoholic Steatohepatitis (NASH) Model Mice by Second Harmonic Generation (SHG) and Auto-Fluorescence (AF) Imaging Using Two-Photon Excitation Microscopy (TPEM). 

Shin Yamamoto, Yusuke Oshima, Takashi Saitou, Takao Watanabe, Teruki Miyake, Osamu Yoshida, Yoshio Tokumoto, Masanori Abe, Bunzo Matsuura, Yoichi Hiasa, Takeshi Imamura. Biochemistry and Biophysics Reports 8 (2016) 277–283;

Automated Evaluation of Liver Fibrosis in CCI4, BDL and TAA Rodent Models Using Second Harmonic Generation / Two-Photon Excited Fluorescence Microscopy

Feng Liu et al. Laboratory Investigation (2016) , 1-9. 2016 USCAP.

New Classification of Liver Biopsy Assessment for Fibrosis in Chronic Hepatitis B Patients Before and After Treatment.

Yameng Sun et all. Journal of Hepatology, doi: 10.1002/hep.29009.

Second Harmonic Generation Microscopy: A Novel Automated Method for Quantification of Hepatic Steatosis in Chronic Liver Disease

George B. Goh, Wei Qiang Leow, Shen Liang, Wei Keat Wan, Dean C. Tai, Kiat Hon Lim, Chee Kiat Tan, Jason P. Chang Poster # 1518 at AASLD 2016.

Phenotypical Characterization of Intrahepatic Cholangiocarcinomas Stroma: The More Fibrous, the Less Pejorative. 

L. Blaise, M. Albuquerque, C. Neuzillet, N. Guedj, J. Cros, V. Paradis, INSERM UMR1149 Beaujon Hospital, Clichy, France, Poster Presentation, AASLD Liver Meeting 2016

Development and Validation of an Automated Optical Imaging System to Differentiate Severity of Hepatitis B- and Non-alcoholic Steatohepatitis-related Fibrosis in Patients with Concomitant Disease

Jason P. Chang, George B. Goh, Wei Qiang Leow, Wei Keat Wan, Dean C. Tai, Kiat Hon Lim, Chee Kiat Tan, Poster # 407 at AASLD 2016.

Objective Quantitative Evaluation of Anti-fibrotic Agents in Animal Models

Kenneth Zhang, Li Chen, Bertha Xue, Chen Hu, Laurent Gole, and Chuan-Chu Chou. Poster #69 at The First International Conference on Tissue Repair, Regeneration , and Fibrosis, September 21-25, 2016.

Evaluation of Liver Fibrosis: "Something Old, Something New..."

Zannis Almpanis, Maria Demonakou, Dina Tiniakos. Ann Gastroenterol 2016; 29 (4): 445-453. DOI:

Automated Biphasic Morphological Assessment of Hepatitis B-related Liver Fibrosis Using Second Harmonic Generation Microscopy.

Tong-Hong Wang, Tse-Ching Chen, Xiao Teng, Kung-Hao Liang & Chau-Ting Yeh. Scientific Reports, 5:12962; DOI: 10.1038/srep12962.

Low Cost and Compact Nonlinear (SHG/TPE) Laser Scanning Endoscope for Bio-medical Application

Liu, J., Lim, K. C., Li, H., Seck, H. L., Yu, X., Kok, S. W., et al. (2015). Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 9304, 93041K-.

Multiphoton Microscopy: A Potential Intraoperative Tool for the Detection of Carcinoma In Situ in Human Bladder

Manu Jain, MD; Brian D. Robinson, MD; Maria M. Shevchuk, MD; Amit Aggarwal, PhD; Bekheit Salamoon, MBBS; Justin M. Dubin, BS; Douglas S. Scherr, MD; Sushmita Mukherjee, PhD, Ms. Arch Pathol Lab Med. 2015; 139:796-804.

Evaluation of Area-based Collagen Scoring by Nonlinear Microscopy in Chronic Hepatitis C-induced Liver Fibrosis

David Sevrain, Matthieu Dubreuil, Grace Elizabeth Dolman, Abed Zaitoun, William Irving, Indra Neil Guha, Christophe Odin, and Yann Le Grand. Biomed. Opt. Express, 1209-1218 (2015).

Digital Whole Slide Imaging and Two Photon Microscopy for Liver Fibrosis Scoring and Quantification

Jolanta Jedrzkiewicz, Mary P Bronner, Erinn Downs-Kelly, Jessica Kohan, Leslie Rowe, Dean Tai, Mohamed Salama. Modern Pathol. 2015; 28(2):167A.

Stain-free Detection of Bone Marrow Fibrosis Using Two Photon Excitation and Second Harmonic Generation Microscopy

Rowe L, Etman A, Kohan J, Prchal J, Ho G, Liu DQ, Salama M. Modern Pathol. 2015; 28(2):523A.

qFibrosis: A Fully Quantitative Innovative Method Incorporating Histological Features to Facilitate Accurate Fibrosis Scoring in Animal Model and Chronic Hepatitis B Patients

Xu S, Wang Yi, Tai DC, et al. Journal of hepatology. 2014.

Differentiation of Col I and Col III Isoforms in Stromal Models of Ovarian Cancer by Analysis of Second Harmonic Generation Polarization and Emission Directionalit

Tilbury K, Lien CH, Chen SJ, Campagnola PJ. Biophysical journal. 2014;106(2):354-65.

Minimally Invasive Multiphoton and Harmonic Generation Imaging of Extracellular Matrix Structures in Lung Airway and Related Diseases. Pulmonary Pharmacology & Therapeutics

Abraham T, Hirota JA, Wadsworth S, Knight DA. 2011;24(5):407-96.

Aligned Collagen is a Prognostic Signature for Survival in Human Breast Carcinoma

Conklin MW, Eickhoff JC, Riching KM, et al. The American journal of pathology. 2011;178(3):1221-32.

Fibro-C-index: Comprehensive, Morphology-based Quantification of Liver Fibrosis Using Second Harmonic Generation and Two-Photon Microscopy

Tai DC, Tan N, Xu S, et al. Journal of biomedical optics. 2009; 14(4):044013.

Nonlinear Optical Microscopy: Use of Second Harmonic Generation and Two-Photon Microscopy for Automated Quantitative Liver Fibrosis Studies

Sun W, Chang S, Tai DC, et al. Journal of biomedical optics. 2008;13(6):064010.

Second Harmonic Microscopy to Quantify Renal Interstitial Fibrosis and Arterial Remodeling.

Strupler, M., Hernest, M., Fligny, C., Martin, J. L., Tharaux, P. L., and Schanne-Klein, M. C. (2008), Journal of biomedical optics 13, 054041