News Room

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May-2015
Chinese Medical Journal - Review Article
Published on 20th January 2015 - "Current Strategies for Quantitating Fibrosis in Liver Biopsy".VIEW MORE
May-2015
Genesis Imaging Service - Inauguration Event
28th May 2015 - Histoindex's partner in the United States, PharmaNest, will celebrate its inauguration event with free discussion on the tissue samples' imaging results. VIEW MORE
Apr-2015
Research Partnership between HistoIndex and the Institute of Molecular and Cell Biology (IMCB), A*STAR
1st May 2015 - HistoIndex and IMCB are embarking on a collaboration to refine image acquisition of stain-free tissue samples of various human diseases and animal disease models, and to conduct processing and analysis in 2D/3D of the stain-free images acquired from HistoIndex Genesis®200 multiphoton imaging system. VIEW MORE
Apr-2015
HistoIndex is 5 years old today!
Histoindex Pte. Ltd. is celebrating its 5th year in the manufacturing and distribution of optical medical imaging technologies.VIEW MORE
Mar-2015
We Are ISO 13485 Certified!
13th March 2015 - 12th March 2018 - HistoIndex's core product, Genesis, is certified with ISO 13485!VIEW MORE
Mar-2015
2015 Annual USCAP Meeting in USA
21st-27th March 2015 - 2015 Annual USCAP Meeting held in Boston, USA.VIEW MORE
Mar-2015
Mr Lee Kuan Yew - 1923 to 2015
HistoIndex mourns the loss of Mr Lee Kuan Yew VIEW MORE
Mar-2015
Laennec Liver Pathology Society Annual Meeting Paris 2015
24th-27th June 2015 - Annual Laennec meeting in ParisVIEW MORE
Mar-2015
24th Conference of APASL 2015, Istanbul
12th-15th March 2015 - 24th Conference of APASL 2015 held in IstanbulVIEW MORE
Feb-2015
HistoIndex Subsidiary Office in Hangzhou, China
Incorporation of a subsidiary office in ChinaVIEW MORE
Jan-2015
HistoIndex and its CEO - Featured
HistoIndex and its CEO were featured on different social media platforms in 2014VIEW MORE
Nov-2014
HistoIndex in partnership with PharmaNest Ltd in USA
On 9th November 2014, an Agreement was made between HistoIndex and PharmaNest Ltd, a company in USA.VIEW MORE
Mar-2014
HistoIndex in partnership with Lifetastic FZ-LLC in Europe
On 1st February 2015, an Exclusive Agency Agreement was signed between HistoIndex and Lifetastic FZ-LLC.VIEW MORE
Feb-2014
Genesis is CE Certified.
HistoIndex's core product Genesis is CE Certified since 2011.VIEW MORE
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References

 

New Standards in Fibrosis Quantification: The Value of Label-free Second Harmonic Generation.

Li Chen, Mathieu Petitjean at the Anti-fibrotic Drug Development Forum, November 13-14, 2017, Boston USA 
 
 

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis (NASH).

Jonathan D Roth, Michael Feigh, Sanne S Veidal, Louise K D Fensholdt, Kristoffer T G Rigbolt, Henrik H Hansen, Li C Chen, Mathieu Petitjean, Weslyn W Friley, Niels Vrang, Jacob Jelsing and Mark Young. 
 
Submitted (10/25) to World Journal of Gastroenterology.

 

Detailed analysis of the antifibrotic effect of INT-767, a dual FXR/TGR5 agonist in an obese mouse model of diet-induced and biopsy-confirmed NASH.

Sanne Skovgård Veidal, Michael Feigh, Henrik B Hansen, Jacob Jelsing, Niels Vrang, Mathieu Petitjean, Li Chen, Mark Young, Jonathan Roth. Presidential Award Poster. Presented at AASLD 2017, October 20-23 , 2017.
 
 

Quantitative Imaging and Deep Profiling of Collagen Structure for Asian Triple Negative Breast Cancer.

Dr Yu Weimiao, presented at the 3rd Digital Pathology Congress Asia-Pacific 2017, Guangzhou, China. 

 

Multiphoton Imaging of Breast Cancer.

Clinnovate Health UK, presented at the Glasgow Molecular Pathology Node Symposium 2017, University of Glasgow.

 

 Novel Methods in Imaging and Quantification of Skeletal Muscle Fibrosis Associated with Severe Muscular Dystrophy.

David W. Hammers, Coar C. Coker, Li Chen, Matt Petitjean, Elizabeth R.  Barton, H.Lee Sweeney, presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017.

 

 Use of Second Harmonic Generation (SHG) and 2-Photon Emission Imaging to Quantify and Describe the Structure of Tissue Fibrosis in the Rat TNBS intestinal fibrosis model.

Laura Johnson, Li.Chen, P. Higgings et all. Poster #2008 presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017.

 

 Concurrent Semi-Automated Quantification of Liver Fibrosis and Fat Using Label-free Second Harmonic Generation Imaging in Animal Models.

M. Petitjean, J. Schwartz, Li Chen. Poster #3003 - presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017

 

 Quantification of Septa in Liver Fibrosis using Second Harmonic Generation Imaging.

Li Chen, Mohammad Naser,  et all. Poster #1016 - presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017

 

 Comparative Efficacy of INT-767 vs. Liraglutide in Gubra AMLN Mice.

Jonathan Roth et All. Intercept Pharmaceuticals. Keystone Symposia Workshop: approaches to NASH Treatment, March 7th 2017.

 

 Quantitative Imaging of Fibrotic and Morphological Changes in Liver of Nonalcoholic Steatohepatitis (NASH) Model Mice by Second Harmonic Generation (SHG) and Auto-Fluorescence (AF) Imaging Using Two-Photon Excitation Microscopy (TPEM).

Shin Yamamoto, Yusuke Oshima, Takashi Saitou, Takao Watanabe, Teruki Miyake, Osamu Yoshida, Yoshio Tokumoto, Masanori Abe, Bunzo Matsuura, Yoichi Hiasa, Takeshi Imamura. Biochemistry and Biophysics Reports 8 (2016) 277–283; https://doi.org/10.1016/j.bbrep.2016.09.010.
 
 

 Automated Evaluation of Liver Fibrosis in CCI4, BDL and TAA Rodent Models Using Second Harmonic Generation (SHG) / Two-Photon Excitation Fluorescence Microscopy. 

Feng Liu et al. Laboratory Investigation (2016) , 1-9. 2016 USCAP

 

 New Classification of Liver Biopsy Assessment for Fibrosis in Chronic Hepatitis B Patients Before and After Treatment.

Yameng Sun et all. Journal of Hepatology, doi: 10.1002/hep.29009

 

 Second Harmonic Generation Microscopy: A Novel Automated Method for Quantification of Hepatic Steatosis in Chronic Liver Disease.

George B. Goh, Wei Qiang Leow, Shen Liang, Wei Keat Wan, Dean C. Tai, Kiat Hon Lim, Chee Kiat Tan, Jason P. Chang Poster # 1518 at AASLD 2016.

 

 Phenotypical Characterization of intrahepatic Cholangiocarcinomas Stroma: The More Fibrous, the Less Pejorative.

L. Blaise, M. Albuquerque, C. Neuzillet, N. Guedj, J. Cros, V. Paradis, INSERM UMR1149 Beaujon Hospital, Clichy, France, Poster Presentation, AASLD Liver Meeting 2016.

 

 Development and Validation of an Automated Optical Imaging System to Differentiate Severity of Hepatitis B- and Non-alcoholic Steatohepatitis-related Fibrosis in Patients with Concomitant Disease.

Jason P. Chang, George B. Goh, Wei Qiang Leow, Wei Keat Wan, Dean C. Tai, Kiat Hon Lim, Chee Kiat Tan, Poster # 407 at AASLD 2016.

 

 Objective Quantitative Evaluation of Anti-fibrotic Agents in Animal Models.

Kenneth Zhang, Li Chen, Bertha Xue, Chen Hu, Laurent Gole, and Chuan-Chu Chou. Poster #69 at The First International Conference on Tissue Repair, Regeneration , and Fibrosis, September 21-25, 2016

 

 Evaluation of Liver Fibrosis: “Something Old, Something New…”

Zannis Almpanis, Maria Demonakou, Dina Tiniakos. Ann Gastroenterol 2016; 29 (4): 445-453. DOI: http://dx.doi.org/10.20524/aog.2016.0046.

 

 Automated Biphasic Morphological Assessment of Hepatitis B-related Liver Fibrosis Using Second Harmonic Generation Microscopy.

Tong-Hong Wang, Tse-Ching Chen, Xiao Teng, Kung-Hao Liang & Chau-Ting Yeh. Scientific Reports, 5:12962; DOI: 10.1038/srep12962

 

 Low Cost and Compact Nonlinear (SGH/TPE) Laser Scanning Endoscope for Bio-medical Application.

Liu, J., Lim, K. C., Li, H., Seck, H. L., Yu, X., Kok, S. W., et al. (2015). Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 9304, 93041K-.

 

 Multiphoton Microscopy: A Potential Intraoperative Tool for the Detection of Carcinoma In Situ in Human Bladder.

Manu Jain, MD; Brian D. Robinson, MD; Maria M. Shevchuk, MD; Amit Aggarwal, PhD; Bekheit Salamoon, MBBS; Justin M. Dubin, BS; Douglas S. Scherr, MD; Sushmita Mukherjee, PhD, Ms. Arch Pathol Lab Med. 2015; 139:796-804

 

 Evaluation of Area-based Collagen Scoring by Nonlinear Microscopy in Chronic Hepatitis C-induced Liver Fibrosis.

David Sevrain, Matthieu Dubreuil, Grace Elizabeth Dolman, Abed Zaitoun, William Irving, Indra Neil Guha, Christophe Odin, and Yann Le Grand. Biomed. Opt. Express, 1209-1218 (2015).

 

 Digital Whole Slide Imaging and Two Photon Microscopy for Liver Fibrosis Scoring and Quantification.

Jolanta Jedrzkiewicz, Mary P Bronner, Erinn Downs-Kelly, Jessica Kohan, Leslie Rowe, Dean Tai, Mohamed Salama. Modern Pathol. 2015; 28(2):167A.

 

 Stain-free Detection of Bone Marrow Fibrosis Using Two-Photon Excitation and Second Harmonic Generation Microscopy.

Rowe L, Etman A, Kohan J, Prchal J, Ho G, Liu DQ, Salama M. Modern Pathol. 2015; 28(2):523A.

               

 Differentiation of Col I and Col III Isoforms in Stromal Models of Ovarian Cancer by Analysis of Second Harmonic Generation Polarization and Emission Directionalit.

Tilbury K, Lien CH, Chen SJ, Campagnola PJ. Biophysical journal. 2014;106(2):354-65.

 

 Minimally Invasive Multiphoton and Harmonic Generation Imaging of Extracellular Matrix Structures in Lung Airway and Related Diseases. Pulmonary Pharmacology & Therapeutics.

Abraham T, Hirota JA, Wadsworth S, Knight DA. 2011;24(5):407-96.

               

 Aligned Collagen is a Prognostic Signature for Survival in Human Breast Carcinoma.

Conklin MW, Eickhoff JC, Riching KM, et al. The American journal of pathology. 2011;178(3):1221-32.

 

 Fibro-C-Index: Comprehensive, Morphology-based Quantification of Liver Fibrosis Using Second Harmonic Generation and Two-photon Microscopy.

Tai DC, Tan N, Xu S, et al. Journal of biomedical optics. 2009; 14(4):044013.

 

 Nonlinear Optical Microscopy: Use of Second Harmonic Generation and Two-photon Microscopy for Automated Quantitative Liver Fibrosis Studies.

Sun W, Chang S, Tai DC, et al. Journal of biomedical optics. 2008;13(6):064010.

 

 Second Harmonic Microscopy to Quantify Renal Interstitial Fibrosis and Arterial Remodeling.

Strupler, M., Hernest, M., Fligny, C., Martin, J. L., Tharaux, P. L., and Schanne-Klein, M. C. (2008), Journal of biomedical optics 13, 054041

 

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis (NASH).

Jonathan D Roth, Michael Feigh, Sanne S Veidal, Louise K D Fensholdt, Kristoffer T G Rigbolt, Henrik H Hansen, Li C Chen, Mathieu Petitjean, Weslyn W Friley, Niels Vrang, Jacob Jelsing and Mark Young. 
 
Submitted (10/25) to World Journal of Gastroenterology.