News Room

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Dec-2015
Histoindex wishes all a very Blessed Christmas!
We wished all our Partners, Board of Directors and Friends a very wonderful holiday and a prosperous New Year!VIEW MORE
Nov-2015
NRF Funded Project - HI working with NTU
Project entitled "Fiber Medical Devices for Diagnosis of Coronary Artery Disease".VIEW MORE
Nov-2015
MPEF Microscopy Shines Best on Living Samples
An article published on BioPhotonics that we find very insightful to shareVIEW MORE
Nov-2015
NUH & Histoindex - Research Collaboration
A joint research collaboration between National University Hospital (NUH) and Histoindex Pte. Ltd (HI)VIEW MORE
Sep-2015
Advances in Tissue Imaging: Non-Destructive, Stain-Free, Novel Techniques for Digital Patholgy and Research
Non-destructive methods are revolutionizing tissue imaging. In this free webinar, you will learn about technologies currently available to accelerate both preclinical and clinical research.VIEW MORE
Sep-2015
Boston-Piranha Tank International & Health-Tech Networking Event (1st Event)
7 high performing Life Science Companies from Singapore will compete for your feedback in a "Piranha Tank" format. This event is free, but registration is required. A chance to win an Apple Watch.VIEW MORE
Sep-2015
New Jersey - Piranha Tank International & Health-Tech Networking Event (2nd Event)
7 high performing Life Science Companies from Singapore will compete for your feedback in a "Piranha Tank" format. This event is free, but registration is required. A chance to win an Apple Watch.VIEW MORE
Sep-2015
Webinar : Fibro-C-Index
Fibro-C-Index: A Unique Quantitative Approach To Assess Liver Fibrosis Progression (stain-free!)VIEW MORE
Aug-2015
Latest Paper of Histoindex's Genesis is published in the Scientific Reports
Published on 11th August 2015 - Title of Paper "Automated Biphasic Morphological Assessment of Hepatitis B-related Liver Fibrosis using Second Harmonic Generation Microscopy" VIEW MORE
Aug-2015
Low cost and compact nonlinear (SHG/TPE) laser scanning endoscope for bio-medical application
This paper was published in Progress in Biomedical Optics and Imaging - Proceedings of SPIEVIEW MORE
Aug-2015
Singapore Celebrates SG50!
Histoindex wishes Singapore a very Happy 50th Birthday!VIEW MORE
Jul-2015
HistoIndex CEO, Dr. Gideon Ho Is Featured on Social Media
As part of the IE Singapore #SgGoesGlobal series, Dr. Gideon Ho, CEO of Histoindex Pte. Ltd., had the privilege to be invited to do an interview and a video to share on a success story to venture overseas as a Singapore SME, on Histoindex's technology and its Genesis200 Imaging system. This interview was aired on Channel News Asia on 1st July 2015.VIEW MORE
Jul-2015
Another Webinar Discussions
Join us on this webinar where Dr. Gideon Ho and Dr. Mathieu Petitjean will briefly introduce the theory and the practical aspects of SHG, coupled with TPEF, for research application in pharmaceutical development. VIEW MORE
Jun-2015
Come Join us on Webinar!
Both Dr. Gideon Ho (from Histoindex Pte. Ltd, Singapore) and Dr. Mathieu Petitjean (from PharmaNest, US), will host a webinar on "Collagen Characterization and Quantification with Non-linear Imaging System"..VIEW MORE
May-2015
Digestive Diseases Week 2015 in USA
16th-19th May 2015 - Digestive Diseases Week 2015, Washington DC, USA.VIEW MORE
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References

 

New Standards in Fibrosis Quantification: The Value of Label-free Second Harmonic Generation.

Li Chen, Mathieu Petitjean at the Anti-fibrotic Drug Development Forum, November 13-14, 2017, Boston USA 
 
 

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis (NASH).

Jonathan D Roth, Michael Feigh, Sanne S Veidal, Louise K D Fensholdt, Kristoffer T G Rigbolt, Henrik H Hansen, Li C Chen, Mathieu Petitjean, Weslyn W Friley, Niels Vrang, Jacob Jelsing and Mark Young. 
 
Submitted (10/25) to World Journal of Gastroenterology.

 

Detailed analysis of the antifibrotic effect of INT-767, a dual FXR/TGR5 agonist in an obese mouse model of diet-induced and biopsy-confirmed NASH.

Sanne Skovgård Veidal, Michael Feigh, Henrik B Hansen, Jacob Jelsing, Niels Vrang, Mathieu Petitjean, Li Chen, Mark Young, Jonathan Roth. Presidential Award Poster. Presented at AASLD 2017, October 20-23 , 2017.
 
 

Quantitative Imaging and Deep Profiling of Collagen Structure for Asian Triple Negative Breast Cancer.

Dr Yu Weimiao, presented at the 3rd Digital Pathology Congress Asia-Pacific 2017, Guangzhou, China. 

 

Multiphoton Imaging of Breast Cancer.

Clinnovate Health UK, presented at the Glasgow Molecular Pathology Node Symposium 2017, University of Glasgow.

 

 Novel Methods in Imaging and Quantification of Skeletal Muscle Fibrosis Associated with Severe Muscular Dystrophy.

David W. Hammers, Coar C. Coker, Li Chen, Matt Petitjean, Elizabeth R.  Barton, H.Lee Sweeney, presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017.

 

 Use of Second Harmonic Generation (SHG) and 2-Photon Emission Imaging to Quantify and Describe the Structure of Tissue Fibrosis in the Rat TNBS intestinal fibrosis model.

Laura Johnson, Li.Chen, P. Higgings et all. Poster #2008 presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017.

 

 Concurrent Semi-Automated Quantification of Liver Fibrosis and Fat Using Label-free Second Harmonic Generation Imaging in Animal Models.

M. Petitjean, J. Schwartz, Li Chen. Poster #3003 - presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017

 

 Quantification of Septa in Liver Fibrosis using Second Harmonic Generation Imaging.

Li Chen, Mohammad Naser,  et all. Poster #1016 - presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017

 

 Comparative Efficacy of INT-767 vs. Liraglutide in Gubra AMLN Mice.

Jonathan Roth et All. Intercept Pharmaceuticals. Keystone Symposia Workshop: approaches to NASH Treatment, March 7th 2017.

 

 Quantitative Imaging of Fibrotic and Morphological Changes in Liver of Nonalcoholic Steatohepatitis (NASH) Model Mice by Second Harmonic Generation (SHG) and Auto-Fluorescence (AF) Imaging Using Two-Photon Excitation Microscopy (TPEM).

Shin Yamamoto, Yusuke Oshima, Takashi Saitou, Takao Watanabe, Teruki Miyake, Osamu Yoshida, Yoshio Tokumoto, Masanori Abe, Bunzo Matsuura, Yoichi Hiasa, Takeshi Imamura. Biochemistry and Biophysics Reports 8 (2016) 277–283; https://doi.org/10.1016/j.bbrep.2016.09.010.
 
 

 Automated Evaluation of Liver Fibrosis in CCI4, BDL and TAA Rodent Models Using Second Harmonic Generation (SHG) / Two-Photon Excitation Fluorescence Microscopy. 

Feng Liu et al. Laboratory Investigation (2016) , 1-9. 2016 USCAP

 

 New Classification of Liver Biopsy Assessment for Fibrosis in Chronic Hepatitis B Patients Before and After Treatment.

Yameng Sun et all. Journal of Hepatology, doi: 10.1002/hep.29009

 

 Second Harmonic Generation Microscopy: A Novel Automated Method for Quantification of Hepatic Steatosis in Chronic Liver Disease.

George B. Goh, Wei Qiang Leow, Shen Liang, Wei Keat Wan, Dean C. Tai, Kiat Hon Lim, Chee Kiat Tan, Jason P. Chang Poster # 1518 at AASLD 2016.

 

 Phenotypical Characterization of intrahepatic Cholangiocarcinomas Stroma: The More Fibrous, the Less Pejorative.

L. Blaise, M. Albuquerque, C. Neuzillet, N. Guedj, J. Cros, V. Paradis, INSERM UMR1149 Beaujon Hospital, Clichy, France, Poster Presentation, AASLD Liver Meeting 2016.

 

 Development and Validation of an Automated Optical Imaging System to Differentiate Severity of Hepatitis B- and Non-alcoholic Steatohepatitis-related Fibrosis in Patients with Concomitant Disease.

Jason P. Chang, George B. Goh, Wei Qiang Leow, Wei Keat Wan, Dean C. Tai, Kiat Hon Lim, Chee Kiat Tan, Poster # 407 at AASLD 2016.

 

 Objective Quantitative Evaluation of Anti-fibrotic Agents in Animal Models.

Kenneth Zhang, Li Chen, Bertha Xue, Chen Hu, Laurent Gole, and Chuan-Chu Chou. Poster #69 at The First International Conference on Tissue Repair, Regeneration , and Fibrosis, September 21-25, 2016

 

 Evaluation of Liver Fibrosis: “Something Old, Something New…”

Zannis Almpanis, Maria Demonakou, Dina Tiniakos. Ann Gastroenterol 2016; 29 (4): 445-453. DOI: http://dx.doi.org/10.20524/aog.2016.0046.

 

 Automated Biphasic Morphological Assessment of Hepatitis B-related Liver Fibrosis Using Second Harmonic Generation Microscopy.

Tong-Hong Wang, Tse-Ching Chen, Xiao Teng, Kung-Hao Liang & Chau-Ting Yeh. Scientific Reports, 5:12962; DOI: 10.1038/srep12962

 

 Low Cost and Compact Nonlinear (SGH/TPE) Laser Scanning Endoscope for Bio-medical Application.

Liu, J., Lim, K. C., Li, H., Seck, H. L., Yu, X., Kok, S. W., et al. (2015). Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 9304, 93041K-.

 

 Multiphoton Microscopy: A Potential Intraoperative Tool for the Detection of Carcinoma In Situ in Human Bladder.

Manu Jain, MD; Brian D. Robinson, MD; Maria M. Shevchuk, MD; Amit Aggarwal, PhD; Bekheit Salamoon, MBBS; Justin M. Dubin, BS; Douglas S. Scherr, MD; Sushmita Mukherjee, PhD, Ms. Arch Pathol Lab Med. 2015; 139:796-804

 

 Evaluation of Area-based Collagen Scoring by Nonlinear Microscopy in Chronic Hepatitis C-induced Liver Fibrosis.

David Sevrain, Matthieu Dubreuil, Grace Elizabeth Dolman, Abed Zaitoun, William Irving, Indra Neil Guha, Christophe Odin, and Yann Le Grand. Biomed. Opt. Express, 1209-1218 (2015).

 

 Digital Whole Slide Imaging and Two Photon Microscopy for Liver Fibrosis Scoring and Quantification.

Jolanta Jedrzkiewicz, Mary P Bronner, Erinn Downs-Kelly, Jessica Kohan, Leslie Rowe, Dean Tai, Mohamed Salama. Modern Pathol. 2015; 28(2):167A.

 

 Stain-free Detection of Bone Marrow Fibrosis Using Two-Photon Excitation and Second Harmonic Generation Microscopy.

Rowe L, Etman A, Kohan J, Prchal J, Ho G, Liu DQ, Salama M. Modern Pathol. 2015; 28(2):523A.

               

 Differentiation of Col I and Col III Isoforms in Stromal Models of Ovarian Cancer by Analysis of Second Harmonic Generation Polarization and Emission Directionalit.

Tilbury K, Lien CH, Chen SJ, Campagnola PJ. Biophysical journal. 2014;106(2):354-65.

 

 Minimally Invasive Multiphoton and Harmonic Generation Imaging of Extracellular Matrix Structures in Lung Airway and Related Diseases. Pulmonary Pharmacology & Therapeutics.

Abraham T, Hirota JA, Wadsworth S, Knight DA. 2011;24(5):407-96.

               

 Aligned Collagen is a Prognostic Signature for Survival in Human Breast Carcinoma.

Conklin MW, Eickhoff JC, Riching KM, et al. The American journal of pathology. 2011;178(3):1221-32.

 

 Fibro-C-Index: Comprehensive, Morphology-based Quantification of Liver Fibrosis Using Second Harmonic Generation and Two-photon Microscopy.

Tai DC, Tan N, Xu S, et al. Journal of biomedical optics. 2009; 14(4):044013.

 

 Nonlinear Optical Microscopy: Use of Second Harmonic Generation and Two-photon Microscopy for Automated Quantitative Liver Fibrosis Studies.

Sun W, Chang S, Tai DC, et al. Journal of biomedical optics. 2008;13(6):064010.

 

 Second Harmonic Microscopy to Quantify Renal Interstitial Fibrosis and Arterial Remodeling.

Strupler, M., Hernest, M., Fligny, C., Martin, J. L., Tharaux, P. L., and Schanne-Klein, M. C. (2008), Journal of biomedical optics 13, 054041

 

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis (NASH).

Jonathan D Roth, Michael Feigh, Sanne S Veidal, Louise K D Fensholdt, Kristoffer T G Rigbolt, Henrik H Hansen, Li C Chen, Mathieu Petitjean, Weslyn W Friley, Niels Vrang, Jacob Jelsing and Mark Young. 
 
Submitted (10/25) to World Journal of Gastroenterology.