News Room

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May-2016
Webinar : Second part of a 3-parts series
Topic on Imaging and Quantification of Idiopathic Pulmonary Fibrosis of the LungVIEW MORE
Apr-2016
Second Harmonic Generation: Imaging and Quantification of Fibrosis of the Liver
This webinar is the first in a 3-part series exploring: Stain free, Non-destructive Imaging and Automated Quantification of Fibrosis of the Liver, Lung, and Kidney by Second Harmonic Generation.VIEW MORE
Apr-2016
Minister S Iswaran's visit to HistoIndex's Office
On 22nd March 2016, HistoIndex had the honor to demo its latest Imaging product, Laennec, to Minister S. Iswaran, Dr. Koh Poh Koon and Ms Low Yen Ling when they paid a visit to HistoIndex's office at Launchpad.VIEW MORE
Mar-2016
Making The Leap from Lab to Market - SPRING News March 2016 Issue
Dr. Gideon Ho shared with SPRING Singapore on how "Local start-up HistoIndex breaks into the world market with its laser-based liver fibrosis detection system"VIEW MORE
Mar-2016
Dr. Gideon Ho - featured on CNA Money Mind
Dr. Gideon Ho, Co-Founder and CEO of Histoindex Pte. Ltd., shared with Channel News Asia Money Mind on its laser-based imaging medical technology, which enables pathologists to diagnose liver fibrosis faster and more accurately.VIEW MORE
Mar-2016
Project Agreement with Singapore Eye Research Institute (SERI)
In November 2015, Histoindex signed a Project Agreement with SERI on "Detection and quantitation of post-surgical fibrosis with biophotonic imaging technology".VIEW MORE
Mar-2016
Research Collaboration Agreement (RCA) between HistoIndex, ETPL and SGH
On 19 October 2015, HistoIndex entered into a Research Collaboration Agreement with Exploit Technologies Pte Ltd (ETPL) and Singapore General Hospital (SGH) to focus on the clinical trials in SGH using HistoIndex's latest clinical imaging system, Laennec™VIEW MORE
Mar-2016
HistoIndex RMB15 Million Co-investment Deal Featured on UpStart - an eNewsletter, published by SPRING Singapore!
HistoIndex's recent joint venture with Qingdao Yaozhu for a co-investment of RMB15 million in China is featured on the UpStart, an eNewsletter for start-ups, published by SPRING Singapore.VIEW MORE
Feb-2016
Histoindex's CEO - Speaker at NMRC Awards Ceremony & Research Symposium 2016
Dr. Gideon Ho, CEO of Histoindex Pte Ltd, is invited to speak at the NMRC Awards Ceremony & Research Symposium 2016 on 25th February 2016.VIEW MORE
Feb-2016
新春快乐! 万事如意!
Histoindex wishes all a Prosperous and Happy Lunar New Year!VIEW MORE
Jan-2016
Foster a stronger collaboration in China in the beginning of 2016!
Histoindex Pte. Ltd signed a RMB15 million co-investment deal with JoinScience MedicalVIEW MORE
Jan-2016
3 Posters Presented at 2015 AASLD
Histoindex had the honor to have 3 posters presented at the recent AASLD Conference in November 2015.VIEW MORE
Dec-2015
Histoindex wishes all a very Blessed Christmas!
We wished all our Partners, Board of Directors and Friends a very wonderful holiday and a prosperous New Year!VIEW MORE
Nov-2015
NRF Funded Project - HI working with NTU
Project entitled "Fiber Medical Devices for Diagnosis of Coronary Artery Disease".VIEW MORE
Nov-2015
MPEF Microscopy Shines Best on Living Samples
An article published on BioPhotonics that we find very insightful to shareVIEW MORE
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References

 Systematic Quantitation of Histologic Patterns Shows Accuracy in Reflecting Cirrhotic Remodeling

Wang Y, Huang W, Li R, Yun Z, Zhu Y, Yang J, Liu H, Liu Z, Feng Q, Hou J. J Gastroenterol Hepatol. 2017 Jan 9. doi: 10.1111/jgh.13722. [Epub ahead of print]

 

 Dual-photon microscopy-based quantitation of fibrosis-related parameters (q-FP) to model disease progression in steatohepatitis.

Wang Y, Vincent R, Yang J, Asgharpour A, Liang X, Idowu MO, Contos MJ, Daitya K, Siddiqui MS, Mirshahi F, Sanyal AJ. Hepatology. 2017 Jun;65(6):1891-1903. doi: 10.1002/hep.29090. Epub 2017 Apr 28.

 

 Novel Methods in Imaging and Quantification of Skeletal Muscle Fibrosis Associated with Severe Muscular Dystrophy.

David W. Hammers, Coar C. Coker, Li Chen, Matt Petitjean, Elizabeth R.  Barton, H.Lee Sweeney presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017.

 

 Use of Second Harmonic Generation (SHG) and 2-Photon Emission Imaging to Quantify and Describe the Structure of Tissue Fibrosis in the Rat TNBS intestinal fibrosis model.

Laura Johnson, Li.Chen, P. Higgings et all. Poster #2008 presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017.

 

 Concurrent Semi-Automated Quantification of Liver Fibrosis and Fat Using Label-free Second Harmonic Generation Imaging in Animal Models.

M. Petitjean, J. Schwartz, Li Chen. Poster #3003 - presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017

 

 Quantification of Septa in Liver Fibrosis using Second Harmonic Generation Imaging.

Li Chen, Mohammad Naser,  et all. Poster #1016 - presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017

 

 Comparative efficacy of INT-767 vs. Liraglutide in Gubra AMLN Mice.

Jonathan Roth et All. Intercept Pharmaceuticals. Keystone Symposia Workshop: approaches to NASH Treatment, March 7th 2017.

 

 Automated evaluation of liver fibrosis in CCl4, BDL and TAA rodent models using Second Harmonic Generation / Two Photon excited fluorescence microscopy.

Feng Liu et al. Laboratory Investigation (2016) , 1-9. 2016 USCAP

 

 New Classification of Liver Biopsy Assessment for Fibrosis in Chronic Hepatitis B Patients Before and After Treatment.

Yameng Sun et all. Journal of Hepatology, doi: 10.1002/hep.29009

 

 Second Harmonic Generation microscopy: a novel automated method for quantification of hepatic steatosis in chronic liver disease.

George B. Goh, Wei Qiang Leow, Shen Liang, Wei Keat Wan, Dean C. Tai, Kiat Hon Lim, Chee Kiat Tan, Jason P. Chang Poster # 1518 at AASLD 2016.

 

 Development and validation of an automated optical imaging system to differentiate severity of hepatitis B- and non-alcoholic steatohepatitis-related fibrosis in patients with concomitant disease.

Jason P. Chang, George B. Goh, Wei Qiang Leow, Wei Keat Wan, Dean C. Tai, Kiat Hon Lim, Chee Kiat Tan, Poster # 407 at AASLC 2016.

 

 Objective quantitative evaluation of anti-fibrotic agents in animal models.

Kenneth Zhang, Li Chen, Bertha Xue, Chen Hu, Laurent Gole, and Chuan-Chu Chou. Poster #69 at The First International Conference on Tissue Repair, Regeneration , and Fibrosis, September 21-25, 2016

 

 Automated biphasic morphological assessment of hepatitis B-related liver fibrosis using second harmonic generation microscopy.

Tong-Hong Wang, Tse-Ching Chen, Xiao Teng, Kung-Hao Liang & Chau-Ting Yeh. Scientific Reports, 5:12962; DOI: 10.1038/srep12962

 

 Low cost and compact nonlinear (SGH/TPE) laser scanning endoscope for bio-medical application.

Liu, J., Lim, K. C., Li, H., Seck, H. L., Yu, X., Kok, S. W., et al. (2015). Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 9304, 93041K-.

 

 A Potential Intraoperative Tool for the Detection of Carcinoma In Situ in Human Bladder.

Manu Jain, MD; Brian D. Robinson, MD; Maria M. Shevchuk, MD; Amit Aggarwal, PhD; Bekheit Salamoon, MBBS; Justin M. Dubin, BS; Douglas S. Scherr, MD; Sushmita Mukherjee, PhD, Ms. Arch Pathol Lab Med. 2015; 139:796-804

 

 Evaluation of area-based collagen scoring by nonlinear microscopy in chronic hepatitis C-induced liver fibrosis 2015.

David Sevrain, Matthieu Dubreuil, Grace Elizabeth Dolman, Abed Zaitoun, William Irving, Indra Neil Guha, Christophe Odin, and Yann Le Grand. Biomed. Opt. Express, 1209-1218 (2015).

 

 Digital Whole Slide Imaging and Two Photon Microscopy for Liver Fibrosis Scoring and Quantification.

Jolanta Jedrzkiewicz, Mary P Bronner, Erinn Downs-Kelly, Jessica Kohan, Leslie Rowe, Dean Tai, Mohamed Salama. Modern Pathol. 2015; 28(2):167A.

 

 Stain-free detection of bone marrow fibrosis using two photon excitation and second harmonic generation microscopy.

Rowe L, Etman A, Kohan J, Prchal J, Ho G, Liu DQ, Salama M. Modern Pathol. 2015; 28(2):523A.

               

 qFibrosis: A fully-quantitative innovative method incorporating histological features to facilitate accurate fibrosis scoring in animal model and chronic hepatitis B patients.

Xu S, Wang Yi, Tai DC, et al. Journal of hepatology. 2014.

 

 Differentiation of Col I and Col III isoforms in stromal models of ovarian cancer by analysis of second harmonic generation polarization and emission directionalit.

Tilbury K, Lien CH, Chen SJ, Campagnola PJ. Biophysical journal. 2014;106(2):354-65.

 

 Minimally invasive multiphoton and harmonic generation imaging of extracellular matrix structures in lung airway and related diseases. Pulmonary pharmacology & therapeutics.

Abraham T, Hirota JA, Wadsworth S, Knight DA. 2011;24(5):407-96.

               

 Aligned collagen is a prognostic signature for survival in human breast carcinoma.

Conklin MW, Eickhoff JC, Riching KM, et al. The American journal of pathology. 2011;178(3):1221-32.

 

 Fibro-C-Index:comprehensive, morphology-based quantification of liver fibrosis using second harmonic generation and two-photon microscopy.

Tai DC, Tan N, Xu S, et al. Journal of biomedical optics. 2009; 14(4):044013.

 

 Nonlinear optical microscopy: use of second harmonic generation and two-photon microscopy for automated quantitative liver fibrosis studies.

Sun W, Chang S, Tai DC, et al. Journal of biomedical optics. 2008;13(6):064010.

 

 Second harmonic microscopy to quantify renal interstitial fibrosis and arterial remodeling.

Strupler, M., Hernest, M., Fligny, C., Martin, J. L., Tharaux, P. L., and Schanne-Klein, M. C. (2008), Journal of biomedical optics 13, 054041