News Room

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Nov-2016
AASLD: The Liver Meeting 2016
3 Posters were presented at the recent AASLD Liver Meeting in Boston.VIEW MORE
Oct-2016
Live Recording - 3rd Webinar on Imaging and Quantification of Fibrosis of the Kidney
Slides & recording of the 3rd and last Webinar of the 3-part series of the Second Harmonic Generation held on 3rd October 2016VIEW MORE
Sep-2016
HistoIndex congratulates Queen Elizabeth University Hospital in Glasgow on its new building!
“Glasgow’s new Queen Elizabeth University Hospital (QEUH) – the largest in Western Europe – is allowing the city to develop a world-class life sciences cluster.” – an article of this £842 million facility is published on the recent September Special Issue of the BQ Scotland Life Sciences magazine.VIEW MORE
Sep-2016
BioImage Informatics Conference 10-12 October, 2016
HistoIndex is one of the main sponsors for this Conference that aims to bring together researchers working in the area of informatics and researchers working in life sciences who uses microscopy as a tool in their research.VIEW MORE
Sep-2016
Press Release : HistoIndex's GIS partner, PharmaNest announced a strategic partnership with GenScript, a leading biotech company in the USA
On 30th August 2016, HIstoIndex's GIS partner, PharmaNest announced a strategic partnership with GenScript to offer services using HistoIndex's Genesis200 smart pathology system for anti-fibrosis drug discoveryVIEW MORE
Aug-2016
Speech by Minister S Iswaran, Minister of Trade and Industry (Industry) on 29th August 2016
Minister S Iswaran made reference to HistoIndex, in the area of medical technology, at the speech at the Germany-Singapore Business Forum 2016 held on 29th August 2016.VIEW MORE
Jul-2016
An abstract presented at the 14th Urological Association of Asia Congress 2016
At the recent UAA 2016 Congress held in Singapore from 20-24 July, an abstract was presented.VIEW MORE
Jul-2016
Leading the Disruption of Tissue Imaging - "We are disrupting something that has not been changed for at least a century."
An article by Dr. Gideon Ho, CEO of HistoIndex, is featured on the Asian Scientist Magazine, July 2016 Issue.VIEW MORE
Jun-2016
Live Recording - 2nd Webinar on Imaging and Quantification of Idiopathic Pulmonary Fibrosis of the Lung
Slides & recording of the 2nd Webinar of the 3-part series on the above held on 8th June 2016.VIEW MORE
Jun-2016
Live Recording - 1st Webinar on Imaging and Quantification of Fibrosis of the Liver
Slides and Recording of the 1st Webinar on the 3-part series of the Second Harmonic Generation held on 9th May 2016.VIEW MORE
May-2016
Webinar : Second part of a 3-parts series
Topic on Imaging and Quantification of Idiopathic Pulmonary Fibrosis of the LungVIEW MORE
Apr-2016
Second Harmonic Generation: Imaging and Quantification of Fibrosis of the Liver
This webinar is the first in a 3-part series exploring: Stain free, Non-destructive Imaging and Automated Quantification of Fibrosis of the Liver, Lung, and Kidney by Second Harmonic Generation.VIEW MORE
Apr-2016
Minister S Iswaran's visit to HistoIndex's Office
On 22nd March 2016, HistoIndex had the honor to demo its latest Imaging product, Laennec, to Minister S. Iswaran, Dr. Koh Poh Koon and Ms Low Yen Ling when they paid a visit to HistoIndex's office at Launchpad.VIEW MORE
Mar-2016
Making The Leap from Lab to Market - SPRING News March 2016 Issue
Dr. Gideon Ho shared with SPRING Singapore on how "Local start-up HistoIndex breaks into the world market with its laser-based liver fibrosis detection system"VIEW MORE
Mar-2016
Dr. Gideon Ho - featured on CNA Money Mind
Dr. Gideon Ho, Co-Founder and CEO of Histoindex Pte. Ltd., shared with Channel News Asia Money Mind on its laser-based imaging medical technology, which enables pathologists to diagnose liver fibrosis faster and more accurately.VIEW MORE
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References

 

New Standards in Fibrosis Quantification: The Value of Label-free Second Harmonic Generation.

Li Chen, Mathieu Petitjean at the Anti-fibrotic Drug Development Forum, November 13-14, 2017, Boston USA 
 
 

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis (NASH).

Jonathan D Roth, Michael Feigh, Sanne S Veidal, Louise K D Fensholdt, Kristoffer T G Rigbolt, Henrik H Hansen, Li C Chen, Mathieu Petitjean, Weslyn W Friley, Niels Vrang, Jacob Jelsing and Mark Young. 
 
Submitted (10/25) to World Journal of Gastroenterology.

 

Detailed analysis of the antifibrotic effect of INT-767, a dual FXR/TGR5 agonist in an obese mouse model of diet-induced and biopsy-confirmed NASH.

Sanne Skovgård Veidal, Michael Feigh, Henrik B Hansen, Jacob Jelsing, Niels Vrang, Mathieu Petitjean, Li Chen, Mark Young, Jonathan Roth. Presidential Award Poster. Presented at AASLD 2017, October 20-23 , 2017.
 
 

Quantitative Imaging and Deep Profiling of Collagen Structure for Asian Triple Negative Breast Cancer.

Dr Yu Weimiao, presented at the 3rd Digital Pathology Congress Asia-Pacific 2017, Guangzhou, China. 

 

Multiphoton Imaging of Breast Cancer.

Clinnovate Health UK, presented at the Glasgow Molecular Pathology Node Symposium 2017, University of Glasgow.

 

 Novel Methods in Imaging and Quantification of Skeletal Muscle Fibrosis Associated with Severe Muscular Dystrophy.

David W. Hammers, Coar C. Coker, Li Chen, Matt Petitjean, Elizabeth R.  Barton, H.Lee Sweeney, presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017.

 

 Use of Second Harmonic Generation (SHG) and 2-Photon Emission Imaging to Quantify and Describe the Structure of Tissue Fibrosis in the Rat TNBS intestinal fibrosis model.

Laura Johnson, Li.Chen, P. Higgings et all. Poster #2008 presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017.

 

 Concurrent Semi-Automated Quantification of Liver Fibrosis and Fat Using Label-free Second Harmonic Generation Imaging in Animal Models.

M. Petitjean, J. Schwartz, Li Chen. Poster #3003 - presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017

 

 Quantification of Septa in Liver Fibrosis using Second Harmonic Generation Imaging.

Li Chen, Mohammad Naser,  et all. Poster #1016 - presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017

 

 Comparative Efficacy of INT-767 vs. Liraglutide in Gubra AMLN Mice.

Jonathan Roth et All. Intercept Pharmaceuticals. Keystone Symposia Workshop: approaches to NASH Treatment, March 7th 2017.

 

 Quantitative Imaging of Fibrotic and Morphological Changes in Liver of Nonalcoholic Steatohepatitis (NASH) Model Mice by Second Harmonic Generation (SHG) and Auto-Fluorescence (AF) Imaging Using Two-Photon Excitation Microscopy (TPEM).

Shin Yamamoto, Yusuke Oshima, Takashi Saitou, Takao Watanabe, Teruki Miyake, Osamu Yoshida, Yoshio Tokumoto, Masanori Abe, Bunzo Matsuura, Yoichi Hiasa, Takeshi Imamura. Biochemistry and Biophysics Reports 8 (2016) 277–283; https://doi.org/10.1016/j.bbrep.2016.09.010.
 
 

 Automated Evaluation of Liver Fibrosis in CCI4, BDL and TAA Rodent Models Using Second Harmonic Generation (SHG) / Two-Photon Excitation Fluorescence Microscopy. 

Feng Liu et al. Laboratory Investigation (2016) , 1-9. 2016 USCAP

 

 New Classification of Liver Biopsy Assessment for Fibrosis in Chronic Hepatitis B Patients Before and After Treatment.

Yameng Sun et all. Journal of Hepatology, doi: 10.1002/hep.29009

 

 Second Harmonic Generation Microscopy: A Novel Automated Method for Quantification of Hepatic Steatosis in Chronic Liver Disease.

George B. Goh, Wei Qiang Leow, Shen Liang, Wei Keat Wan, Dean C. Tai, Kiat Hon Lim, Chee Kiat Tan, Jason P. Chang Poster # 1518 at AASLD 2016.

 

 Phenotypical Characterization of intrahepatic Cholangiocarcinomas Stroma: The More Fibrous, the Less Pejorative.

L. Blaise, M. Albuquerque, C. Neuzillet, N. Guedj, J. Cros, V. Paradis, INSERM UMR1149 Beaujon Hospital, Clichy, France, Poster Presentation, AASLD Liver Meeting 2016.

 

 Development and Validation of an Automated Optical Imaging System to Differentiate Severity of Hepatitis B- and Non-alcoholic Steatohepatitis-related Fibrosis in Patients with Concomitant Disease.

Jason P. Chang, George B. Goh, Wei Qiang Leow, Wei Keat Wan, Dean C. Tai, Kiat Hon Lim, Chee Kiat Tan, Poster # 407 at AASLD 2016.

 

 Objective Quantitative Evaluation of Anti-fibrotic Agents in Animal Models.

Kenneth Zhang, Li Chen, Bertha Xue, Chen Hu, Laurent Gole, and Chuan-Chu Chou. Poster #69 at The First International Conference on Tissue Repair, Regeneration , and Fibrosis, September 21-25, 2016

 

 Evaluation of Liver Fibrosis: “Something Old, Something New…”

Zannis Almpanis, Maria Demonakou, Dina Tiniakos. Ann Gastroenterol 2016; 29 (4): 445-453. DOI: http://dx.doi.org/10.20524/aog.2016.0046.

 

 Automated Biphasic Morphological Assessment of Hepatitis B-related Liver Fibrosis Using Second Harmonic Generation Microscopy.

Tong-Hong Wang, Tse-Ching Chen, Xiao Teng, Kung-Hao Liang & Chau-Ting Yeh. Scientific Reports, 5:12962; DOI: 10.1038/srep12962

 

 Low Cost and Compact Nonlinear (SGH/TPE) Laser Scanning Endoscope for Bio-medical Application.

Liu, J., Lim, K. C., Li, H., Seck, H. L., Yu, X., Kok, S. W., et al. (2015). Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 9304, 93041K-.

 

 Multiphoton Microscopy: A Potential Intraoperative Tool for the Detection of Carcinoma In Situ in Human Bladder.

Manu Jain, MD; Brian D. Robinson, MD; Maria M. Shevchuk, MD; Amit Aggarwal, PhD; Bekheit Salamoon, MBBS; Justin M. Dubin, BS; Douglas S. Scherr, MD; Sushmita Mukherjee, PhD, Ms. Arch Pathol Lab Med. 2015; 139:796-804

 

 Evaluation of Area-based Collagen Scoring by Nonlinear Microscopy in Chronic Hepatitis C-induced Liver Fibrosis.

David Sevrain, Matthieu Dubreuil, Grace Elizabeth Dolman, Abed Zaitoun, William Irving, Indra Neil Guha, Christophe Odin, and Yann Le Grand. Biomed. Opt. Express, 1209-1218 (2015).

 

 Digital Whole Slide Imaging and Two Photon Microscopy for Liver Fibrosis Scoring and Quantification.

Jolanta Jedrzkiewicz, Mary P Bronner, Erinn Downs-Kelly, Jessica Kohan, Leslie Rowe, Dean Tai, Mohamed Salama. Modern Pathol. 2015; 28(2):167A.

 

 Stain-free Detection of Bone Marrow Fibrosis Using Two-Photon Excitation and Second Harmonic Generation Microscopy.

Rowe L, Etman A, Kohan J, Prchal J, Ho G, Liu DQ, Salama M. Modern Pathol. 2015; 28(2):523A.

               

 Differentiation of Col I and Col III Isoforms in Stromal Models of Ovarian Cancer by Analysis of Second Harmonic Generation Polarization and Emission Directionalit.

Tilbury K, Lien CH, Chen SJ, Campagnola PJ. Biophysical journal. 2014;106(2):354-65.

 

 Minimally Invasive Multiphoton and Harmonic Generation Imaging of Extracellular Matrix Structures in Lung Airway and Related Diseases. Pulmonary Pharmacology & Therapeutics.

Abraham T, Hirota JA, Wadsworth S, Knight DA. 2011;24(5):407-96.

               

 Aligned Collagen is a Prognostic Signature for Survival in Human Breast Carcinoma.

Conklin MW, Eickhoff JC, Riching KM, et al. The American journal of pathology. 2011;178(3):1221-32.

 

 Fibro-C-Index: Comprehensive, Morphology-based Quantification of Liver Fibrosis Using Second Harmonic Generation and Two-photon Microscopy.

Tai DC, Tan N, Xu S, et al. Journal of biomedical optics. 2009; 14(4):044013.

 

 Nonlinear Optical Microscopy: Use of Second Harmonic Generation and Two-photon Microscopy for Automated Quantitative Liver Fibrosis Studies.

Sun W, Chang S, Tai DC, et al. Journal of biomedical optics. 2008;13(6):064010.

 

 Second Harmonic Microscopy to Quantify Renal Interstitial Fibrosis and Arterial Remodeling.

Strupler, M., Hernest, M., Fligny, C., Martin, J. L., Tharaux, P. L., and Schanne-Klein, M. C. (2008), Journal of biomedical optics 13, 054041

 

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis (NASH).

Jonathan D Roth, Michael Feigh, Sanne S Veidal, Louise K D Fensholdt, Kristoffer T G Rigbolt, Henrik H Hansen, Li C Chen, Mathieu Petitjean, Weslyn W Friley, Niels Vrang, Jacob Jelsing and Mark Young. 
 
Submitted (10/25) to World Journal of Gastroenterology.