News Room

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8th SGH Breast Pathology Course: Microscopy Workshop
Calling all practising pathologists, pathology fellows and residents, as well as oncologists and researchers in Singapore!VIEW MORE
HistoIndex Receives Frost & Sullivan 2017 Asia-Pacific Best Practices Award for Innovative Diagnostics in the Area of Nonalcoholic Steatohepatitis (NASH)
Histoindex Pte. Ltd. has been presented with the 2017 Asia-Pacific Nonalcoholic Steatohepatitis (NASH) Diagnostics New Product Innovation Award by Frost & Sullivan. The award is a testament of the achievements by HistoIndex and the impact of its proprietary technologies on aiding clinical diagnosis and the development of NASH therapeutics.VIEW MORE
Asian Scientist Magazine - Exposing A Silent Killer: Liver Disease
Genesis®200 is able to accurately stratify fibrosis due to NASH, and is expected to set a new standard for its diagnosis in the near future. Read more on the world's first stain-free and multiphoton digital pathology system by Histoindex Pte Ltd and its commitment in combating NASH in the Asian Scientist Magazine.VIEW MORE
The Straits Times - Building ties in pharma industry 'just like courtship'
Here it is! The Straits Times sat down with our CEO, Dr Gideon Ho, to find out how Histoindex Pte Ltd's Genesis® system is breaking new grounds in developing drugs for liver conditions, particularly non-alcoholic steatohepatitis (NASH).VIEW MORE
Lights! Camera! Action!
HistoIndex sits down for a chat with The Straits Times.VIEW MORE
Evolution of the IP Office
In this article, HistoIndex's used of the IP strategy to drive its business growth was cited as an example by the Chief Executive, Daren Tang, of the Intellectual Property Office of Singapore.VIEW MORE
HistoIndex wishes all a very Blessed Christmas and a Happy New Year!
We wish all our Partners, Board of Directors and Friends a very joyous Christmas and prosperous New Year! VIEW MORE
Straits Times - Beautiful Science
A winning scientific image, using Histoindex's Genesis®200 & combined with immunofluorescent staining, is published in the Straits Times today, 9th December 2016 - under the Beautiful Science section.VIEW MORE
AASLD: The Liver Meeting 2016
3 Posters were presented at the recent AASLD Liver Meeting in Boston.VIEW MORE
Live Recording - 3rd Webinar on Imaging and Quantification of Fibrosis of the Kidney
Slides & recording of the 3rd and last Webinar of the 3-part series of the Second Harmonic Generation held on 3rd October 2016VIEW MORE
HistoIndex congratulates Queen Elizabeth University Hospital in Glasgow on its new building!
“Glasgow’s new Queen Elizabeth University Hospital (QEUH) – the largest in Western Europe – is allowing the city to develop a world-class life sciences cluster.” – an article of this £842 million facility is published on the recent September Special Issue of the BQ Scotland Life Sciences magazine.VIEW MORE
BioImage Informatics Conference 10-12 October, 2016
HistoIndex is one of the main sponsors for this Conference that aims to bring together researchers working in the area of informatics and researchers working in life sciences who uses microscopy as a tool in their research.VIEW MORE
Press Release : HistoIndex's GIS partner, PharmaNest announced a strategic partnership with GenScript, a leading biotech company in the USA
On 30th August 2016, HIstoIndex's GIS partner, PharmaNest announced a strategic partnership with GenScript to offer services using HistoIndex's Genesis200 smart pathology system for anti-fibrosis drug discoveryVIEW MORE
Speech by Minister S Iswaran, Minister of Trade and Industry (Industry) on 29th August 2016
Minister S Iswaran made reference to HistoIndex, in the area of medical technology, at the speech at the Germany-Singapore Business Forum 2016 held on 29th August 2016.VIEW MORE
An abstract presented at the 14th Urological Association of Asia Congress 2016
At the recent UAA 2016 Congress held in Singapore from 20-24 July, an abstract was presented.VIEW MORE
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New Standards in Fibrosis Quantification: The Value of Label-free Second Harmonic Generation.

Li Chen, Mathieu Petitjean at the Anti-fibrotic Drug Development Forum, November 13-14, 2017, Boston USA 

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis (NASH).

Jonathan D Roth, Michael Feigh, Sanne S Veidal, Louise K D Fensholdt, Kristoffer T G Rigbolt, Henrik H Hansen, Li C Chen, Mathieu Petitjean, Weslyn W Friley, Niels Vrang, Jacob Jelsing and Mark Young. 
Submitted (10/25) to World Journal of Gastroenterology.


Detailed analysis of the antifibrotic effect of INT-767, a dual FXR/TGR5 agonist in an obese mouse model of diet-induced and biopsy-confirmed NASH.

Sanne Skovgård Veidal, Michael Feigh, Henrik B Hansen, Jacob Jelsing, Niels Vrang, Mathieu Petitjean, Li Chen, Mark Young, Jonathan Roth. Presidential Award Poster. Presented at AASLD 2017, October 20-23 , 2017.

Quantitative Imaging and Deep Profiling of Collagen Structure for Asian Triple Negative Breast Cancer.

Dr Yu Weimiao, presented at the 3rd Digital Pathology Congress Asia-Pacific 2017, Guangzhou, China. 


Multiphoton Imaging of Breast Cancer.

Clinnovate Health UK, presented at the Glasgow Molecular Pathology Node Symposium 2017, University of Glasgow.


 Novel Methods in Imaging and Quantification of Skeletal Muscle Fibrosis Associated with Severe Muscular Dystrophy.

David W. Hammers, Coar C. Coker, Li Chen, Matt Petitjean, Elizabeth R.  Barton, H.Lee Sweeney, presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017.


 Use of Second Harmonic Generation (SHG) and 2-Photon Emission Imaging to Quantify and Describe the Structure of Tissue Fibrosis in the Rat TNBS intestinal fibrosis model.

Laura Johnson, Li.Chen, P. Higgings et all. Poster #2008 presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017.


 Concurrent Semi-Automated Quantification of Liver Fibrosis and Fat Using Label-free Second Harmonic Generation Imaging in Animal Models.

M. Petitjean, J. Schwartz, Li Chen. Poster #3003 - presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017


 Quantification of Septa in Liver Fibrosis using Second Harmonic Generation Imaging.

Li Chen, Mohammad Naser,  et all. Poster #1016 - presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017


 Comparative Efficacy of INT-767 vs. Liraglutide in Gubra AMLN Mice.

Jonathan Roth et All. Intercept Pharmaceuticals. Keystone Symposia Workshop: approaches to NASH Treatment, March 7th 2017.


 Quantitative Imaging of Fibrotic and Morphological Changes in Liver of Nonalcoholic Steatohepatitis (NASH) Model Mice by Second Harmonic Generation (SHG) and Auto-Fluorescence (AF) Imaging Using Two-Photon Excitation Microscopy (TPEM).

Shin Yamamoto, Yusuke Oshima, Takashi Saitou, Takao Watanabe, Teruki Miyake, Osamu Yoshida, Yoshio Tokumoto, Masanori Abe, Bunzo Matsuura, Yoichi Hiasa, Takeshi Imamura. Biochemistry and Biophysics Reports 8 (2016) 277–283;

 Automated Evaluation of Liver Fibrosis in CCI4, BDL and TAA Rodent Models Using Second Harmonic Generation (SHG) / Two-Photon Excitation Fluorescence Microscopy. 

Feng Liu et al. Laboratory Investigation (2016) , 1-9. 2016 USCAP


 New Classification of Liver Biopsy Assessment for Fibrosis in Chronic Hepatitis B Patients Before and After Treatment.

Yameng Sun et all. Journal of Hepatology, doi: 10.1002/hep.29009


 Second Harmonic Generation Microscopy: A Novel Automated Method for Quantification of Hepatic Steatosis in Chronic Liver Disease.

George B. Goh, Wei Qiang Leow, Shen Liang, Wei Keat Wan, Dean C. Tai, Kiat Hon Lim, Chee Kiat Tan, Jason P. Chang Poster # 1518 at AASLD 2016.


 Phenotypical Characterization of intrahepatic Cholangiocarcinomas Stroma: The More Fibrous, the Less Pejorative.

L. Blaise, M. Albuquerque, C. Neuzillet, N. Guedj, J. Cros, V. Paradis, INSERM UMR1149 Beaujon Hospital, Clichy, France, Poster Presentation, AASLD Liver Meeting 2016.


 Development and Validation of an Automated Optical Imaging System to Differentiate Severity of Hepatitis B- and Non-alcoholic Steatohepatitis-related Fibrosis in Patients with Concomitant Disease.

Jason P. Chang, George B. Goh, Wei Qiang Leow, Wei Keat Wan, Dean C. Tai, Kiat Hon Lim, Chee Kiat Tan, Poster # 407 at AASLD 2016.


 Objective Quantitative Evaluation of Anti-fibrotic Agents in Animal Models.

Kenneth Zhang, Li Chen, Bertha Xue, Chen Hu, Laurent Gole, and Chuan-Chu Chou. Poster #69 at The First International Conference on Tissue Repair, Regeneration , and Fibrosis, September 21-25, 2016


 Evaluation of Liver Fibrosis: “Something Old, Something New…”

Zannis Almpanis, Maria Demonakou, Dina Tiniakos. Ann Gastroenterol 2016; 29 (4): 445-453. DOI:


 Automated Biphasic Morphological Assessment of Hepatitis B-related Liver Fibrosis Using Second Harmonic Generation Microscopy.

Tong-Hong Wang, Tse-Ching Chen, Xiao Teng, Kung-Hao Liang & Chau-Ting Yeh. Scientific Reports, 5:12962; DOI: 10.1038/srep12962


 Low Cost and Compact Nonlinear (SGH/TPE) Laser Scanning Endoscope for Bio-medical Application.

Liu, J., Lim, K. C., Li, H., Seck, H. L., Yu, X., Kok, S. W., et al. (2015). Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 9304, 93041K-.


 Multiphoton Microscopy: A Potential Intraoperative Tool for the Detection of Carcinoma In Situ in Human Bladder.

Manu Jain, MD; Brian D. Robinson, MD; Maria M. Shevchuk, MD; Amit Aggarwal, PhD; Bekheit Salamoon, MBBS; Justin M. Dubin, BS; Douglas S. Scherr, MD; Sushmita Mukherjee, PhD, Ms. Arch Pathol Lab Med. 2015; 139:796-804


 Evaluation of Area-based Collagen Scoring by Nonlinear Microscopy in Chronic Hepatitis C-induced Liver Fibrosis.

David Sevrain, Matthieu Dubreuil, Grace Elizabeth Dolman, Abed Zaitoun, William Irving, Indra Neil Guha, Christophe Odin, and Yann Le Grand. Biomed. Opt. Express, 1209-1218 (2015).


 Digital Whole Slide Imaging and Two Photon Microscopy for Liver Fibrosis Scoring and Quantification.

Jolanta Jedrzkiewicz, Mary P Bronner, Erinn Downs-Kelly, Jessica Kohan, Leslie Rowe, Dean Tai, Mohamed Salama. Modern Pathol. 2015; 28(2):167A.


 Stain-free Detection of Bone Marrow Fibrosis Using Two-Photon Excitation and Second Harmonic Generation Microscopy.

Rowe L, Etman A, Kohan J, Prchal J, Ho G, Liu DQ, Salama M. Modern Pathol. 2015; 28(2):523A.


 Differentiation of Col I and Col III Isoforms in Stromal Models of Ovarian Cancer by Analysis of Second Harmonic Generation Polarization and Emission Directionalit.

Tilbury K, Lien CH, Chen SJ, Campagnola PJ. Biophysical journal. 2014;106(2):354-65.


 Minimally Invasive Multiphoton and Harmonic Generation Imaging of Extracellular Matrix Structures in Lung Airway and Related Diseases. Pulmonary Pharmacology & Therapeutics.

Abraham T, Hirota JA, Wadsworth S, Knight DA. 2011;24(5):407-96.


 Aligned Collagen is a Prognostic Signature for Survival in Human Breast Carcinoma.

Conklin MW, Eickhoff JC, Riching KM, et al. The American journal of pathology. 2011;178(3):1221-32.


 Fibro-C-Index: Comprehensive, Morphology-based Quantification of Liver Fibrosis Using Second Harmonic Generation and Two-photon Microscopy.

Tai DC, Tan N, Xu S, et al. Journal of biomedical optics. 2009; 14(4):044013.


 Nonlinear Optical Microscopy: Use of Second Harmonic Generation and Two-photon Microscopy for Automated Quantitative Liver Fibrosis Studies.

Sun W, Chang S, Tai DC, et al. Journal of biomedical optics. 2008;13(6):064010.


 Second Harmonic Microscopy to Quantify Renal Interstitial Fibrosis and Arterial Remodeling.

Strupler, M., Hernest, M., Fligny, C., Martin, J. L., Tharaux, P. L., and Schanne-Klein, M. C. (2008), Journal of biomedical optics 13, 054041


INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis (NASH).

Jonathan D Roth, Michael Feigh, Sanne S Veidal, Louise K D Fensholdt, Kristoffer T G Rigbolt, Henrik H Hansen, Li C Chen, Mathieu Petitjean, Weslyn W Friley, Niels Vrang, Jacob Jelsing and Mark Young. 
Submitted (10/25) to World Journal of Gastroenterology.